Staff profile for A/Prof Philip Siddall

Position

Clinical Associate Professor, Principal Research Fellow, Director of Education Program

Job description

Neurobiologist, Director of Education Program

Organisation

Neurobiologist, Director of Education Program, University of Sydney

Qualifications

MBBS, MM(PainMgt), PhD, FFPMANZCA

Education

• 1980 MBBS University of Sydney
• 1982 Dip Chinese Lang Beijing Languages Institute
• 1984 Grad. Dip Acup Beijing College of Traditional Chinese Medicine
• 1993 PhD University of Sydney
• 1999 MM (Pain Management) University of Sydney

Research interests

Neuropathic pain, particularly following spinal cord injury. Previous work includes studies of the mechanisms and management of pain following spinal cord injury. These include studies investigating spinal and thalamic mechanisms contributing to pain, prevalence, characteristics and classification of spinal cord injury pain and oral and intrathecal drug treatment for the management of pain following spinal cord injury. Current work is focusing on brain mechanisms contributing to neuropathic pain following spinal cord injury using functional brain imaging techniques.

Project

• Investigation of alterations in brain biochemistry associated with pain following spinal cord injury.
• Investigation of changes in brain electrical activity in people with neuropathic pain following spinal cord injury.
• Cortical reorganisation and its association with neuropathic pain following spinal cord injury.

Grants/Awards

• Australian and New Zealand College of Anaesthetists “Activation of brain regions in people with neuropathic pain following spinal cord injury” A/Prof P Siddall, Dr J Middleton. 2007.
• NSW Government Spinal Cord Injury Research Grants Program “Pain following spinal cord injury: understanding mechanisms to develop treatments” A/Prof J Keast, Prof M Christie, Dr P Osborne, Prof M Cousins, A/Prof P Siddall; 2005-2008.

Publications

Gustin SM, Wrigley PJ, Gandevia SC, Middleton JW, Henderson LA, Siddall PJ. Movement imagery increases pain in people with neuropathic pain following complete thoracic spinal cord injury, Pain, (advance online publication 15 Oct 2007  doi:10.1016/j.pain.2007.08.032)

Murray RF, Asghari A, Egorov DD, Rutkowski RB, Siddall PJ, Soden RJ, Ruff R, (2007) Impact of spinal cord injury and pain on self-perceived pre and postmorbid cognitive, emotional and physical functioning, Spinal Cord, 45: 429-436. (advance online publication 16 January 2007; doi: 10.1038/sj.sc.3102022).

Vikman KS, Duggan AW, Siddall PJ (2007) Interferon-γ induced disruption of GABAergic inhibition in the spinal dorsal horn in vivo, Pain, (advance online publication 2 April 2007; doi:10.1016/j.pain.2007.02.010)

Boord P, Siddall PJ, Tran Y, Herbert D, Middleton J, Craig A (2007) Electroencephalographic slowing and reduced reactivity in neuropathic pain following spinal cord injury, Spinal Cord (advance online publication 5 May 2007 doi:10.1038/sj.sc.3102077).

Allbutt HN, Siddall PJ, Keay KA. (2007) Contusive spinal cord injury evokes localized changes in NADPH-d activity but extensive changes in Fos-like immunoreactivity in the rat. Journal of Anatomy 211:352-70.

Wrigley PJ, Siddall PJ (2007) Pharmacological interventions for neuropathic pain following spinal cord injury: an update, Topics in Spinal Cord Injury Rehabilitation 13: 58-71.

Richards JS, Siddall P, Bryce T, Dijkers M, Cardenas D. (2007) Spinal cord injury pain classification: history, current trends, and commentary, Topics in Spinal Cord Injury Rehabilitation, 13:1-19.

Que JC, Siddall PJ, Cousins MJ. (2007) Pain management in a patient with intractable spinal cord injury pain: a case report and literature review. Anesthesia & Analgesia 105(5):1462-1473.

Herbert D, Tran Y, Craig A, Boord P, Middleton J, Siddall P (2007) Altered brain wave activity in persons with chronic spinal cord injury. International Journal of Neuroscience, 117 (12):1731-1746.

Siddall PJ, Cousins MJ, Otte A, Griesing T, Chambers R, Murphy TK (2006) Pregabalin in central neuropathic pain associated with spinal cord injury: A placebo-controlled trial, Neurology, 67:1792-1800.

Smeal WL, Yezierski RP, Wrigley PJ, Siddall PJ, Jensen MP, Ehde DM.  Spinal Cord Injury.  J Pain. 2006 Dec;7(12):871-7.

Siddall PJ, Middleton JW. (2006) A proposed algorithm for the management of pain following spinal cord injury. Spinal Cord, 44: 67-77 (advance online publication, August 23, 2005; doi:10.1038/sj.sc.3101824)

Siddall PJ, Stanwell P, Woodhouse A, Somorjai RL, Dolenko B, Nikulin A, Bourne R, Himmelreich U, Lean C, Cousins MJ, Mountford CE.  Magnetic resonance spectroscopy detects biochemical changes in the brain associated with chronic low back pain: a preliminary report, Anesthesia & Analgesia. 2006 Apr;102(4):1164-8.

Siddall, P.J. (2006) Pain following spinal cord injury. In: McMahon, S. and Koltzenburg M. Wall & Melzack's Textbook of Pain, 5th Edition, Churchill Livingstone, London, pp. 1043-1055.

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